Tramadol and 0.5% levobupivacaine for single-shot interscalene block: effects on postoperative... - Abstract - Europe PMC
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F Alemanno
Department of Anesthesia and Pain Therapy, Ospedale San Camillo, Brescia, Italy.
B Pergolotti
F Bizzarri
Department of Anesthesia and Pain Therapy, Ospedale San Camillo, Brescia, Italy.
No matching affiliation detected.
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[):291-296]
Journal Article, Randomized Controlled Trial
The aim of this study was to evaluate the efficacy of tramadol as an adjuvant to the local anaesthetic solution in patients undergoing shoulder arthroscopy for rotator cuff tear after middle interscalene block (MIB).We enrolled 120 patients (ASA I-II), scheduled for arthroscopic surgery for rotator cuff tear. The patients were sedated with midazolam 0.02 mg/kg and haloperidol 2 mg i.v. before performing MIB. All subjects underwent a MIB with 0.4 mL/kg of 0.5% levobupivacaine. After computerized randomization, all patients were allocated in 1 of 3 groups, each including 40 subjects. Group Placebo (Group P) received 0.4 mL/kg of 0.5% levobupivacaine plus isotonic sodium chloride for MIB and isotonic sodium chloride i.m. Group &Perineural Tramadol& (Group TPN) received 0.4 ml/Kg of 0.5% levobupivacaine plus 1.5 mg/kg of tramadol perineurally and isotonic sodium chloride i.m. Group &Intramuscular Tramadol& (Group TIM) received 0.4 ml/Kg of 0.5% levobupivacaine plus isotonic sodium chloride perineurally and 1.5 mg/kg of tramadol i.m.The MIB onset times were not statistically different in the three groups. The duration of analgesia was significantly longer in Groups TPN and TIM, where tramadol was administered, either i.m. or perineurally, compared with the placebo group. A significant statistical difference was found in the duration of analgesia between the group TPN and TIM.The addition of tramadol to the local anaesthetic solution administered for MIB provided a longer duration of analgesia compared with placebo and i.m tramadol administration in patients undergoing arthroscopic surgery for rotator cuff tear.
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Allostimulatory analysis of a newly-defined and widely-distributed Mls superantigenJohn J. RyanH. Baltzer LeJeuneJames J. MondFred D. FinkelmanOriginal ArticlesDOI:
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A gradient of stimulatory capacity from low to high across this newly-defined non-MHC difference was detected with splenocytes from these different inbred mouse strains. The Mlsa,c genetic composition of C58/J was confirmed by the observation that crossing C58/J with parental B10.BR (responsive to both Mlsa and Mlsc determinants) generated F1 progeny that were unresponsive to H-2k-compatible Mlsa, Mlsc, or Mlsa,c stimulator cells. Like prototypic Mlsa and Mlsc, the non-MHC specificity recognized by C58/J responder cells, termed Mlsf, was particularly sensitive to radiation (versus mitomycin C) treatment of the stimulator cells, was greatly augmented after anti-IgD activation of splenic stimulator cells, was blocked with anti-MHC class II antibody, and was effectively presented by phenotypically normal female but not B cell-defective xid+ male CBA/N F1 stimulator cells.Abe, R. and Hodes, R. J.: T cell recognition of Mlsc. I. 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Finkelman21.Immunobiology and Transplantation DepartmentNaval Medical ResearchInstituteBethesdaUSA2.Department of MedicineUniformed Services University of the Health SciencesBethesdaUSA
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