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中国贝类学会理事、广东海洋学会水生生物专业委员会副主任委员、国家贝类产业技术研发中心 研究室岗位科学家、《热带海洋学报》编委、美国甲壳贝类学会会员、世界牡蛎学会会员
广州市新港西路164号 510301，中国科学院南海海洋研究所
&&& 喻子牛，1962年生，湖南湘潭人，中国科学院研究员、博士生导师，中国科学院湛江海洋经济动物实验站站长。2005年初入选中科院“引进国外杰出人才计划”（百人计划），进入南海海洋研究所工作。现任中国贝类学会常务理事、国家贝类产业技术研发中心&育种与繁育& 研究室岗位专家、科技部国际科技合作项目评审专家、《热带海洋学报》和《American Journal of Molecular and Cellular Biology》(USA) 编委、美国甲壳贝类学会（NSA）和世界牡蛎学会（WOS）会员。
&&& 1979-83年间于湖南师范大学生物系学习，获学士学位；1986年山东大学生物系研究生毕业，获硕士学位，同年进入青岛海洋大学，从事水产生物遗传学与育种学的教学和科研工作；1997年在青岛海洋大学获博士学位；年间分别在美国两所大学（University of Delaware和The State University of New Jersey）作为博士后和高级研究助理（Senior Research Associate）从事了5年多的海洋贝类遗传学与分子生物学研究，期间除参加多项课题外，曾申请并主持NOAA（National Sea Grant）课题一项。
&&& 多年来先后主持和参与了多项国家和省部级科研项目，包括863课题、973课题、国家自然科学基金课题及重点课题、国家公益性农业专项、国家现代农业技术体系建设专项、中国科学院知识创新重要方向性项目、创新团队国际合作伙伴计划项目、广东省自然科学基金重点课题等。目前主要从事贝类遗传学与育种学、分子生物学与基因组学、分子系统学研究，取得了一系列创新性学术成果，在国内外学术期刊发表论文100余篇，其中SCI收录论文50篇, 专利3项；并与美国、法国、澳洲、香港等国家和地区同行建立了实际的联系和合作。
&研究领域：
(1)贝类遗传学与育种研究：&开发、利用微卫星、SNP、mtDNA等分子标记，进行遗传多样性、群体遗传结构解析、育种过程中遗传变化的监测与评价、种类鉴定等；通过连锁分析进行遗传连锁图构建；利用家系选择、群体选择、多倍体和杂交进行牡蛎优良品种培育。(2) 贝类功能基因与基因组学：&利用各种分子生物学和生物信息学技术, 以及转录组、表达谱分析，研究性状的分子基础，解析基因组特征；通过性状相关的功能基因筛选、克隆、表达分析，研究其分子水平的功能和调控，为性状解析和良种培育提供可供利用的基因、基因组信息和工具。&(3)贝类线粒体基因组与分子系统学：&通过线粒体基因组测序和分析，运用分子系统学理论和方法，研究、比较贝类线粒体基因组的结构与变化、基因重排及其进化，进行种类鉴定；解析并探讨贝类种、属、科等各种类间、类群间的系统关系和地位。&
&社会任职：
&获奖及荣誉：
&代表论著：
1.&Dineshram, R. V. Thiyagarajan, A. Lane, Z. Yu, S. Xiao, Priscilla T. Y. Leung. 2013, Elevated CO2 alters larval proteome and its phosphorylation status in the commercial oyster, Crassostrea hongkongensis. Mar Biol. DOI 10.-013-2176-x
2.&Zhang, Y., J. Li, F. Yu, X. He and Z. Yu*, 2013, Allograft inflammatory factor-1 stimulates hemocyte immune activation by enhancing phagocytosis and expression of inflammatory cytokines in Crassostrea gigas. Fish Shellfish Immunol. 34:.
3.&Zhang, Y., Z. Yu*, 2013, The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas. Fish Shellfish Immunol. 34:.
4.&Li, J., J. Chen, Y. Zhang and Z. Yu*, 2013, Expression of Allograft inflammatory factor-1 (AIF-1) in response to bacterial challenge and tissue injury in the pearl oyster, Pinctada martensii.Fish Shellfish Immunol. 34:365- 371.
5.&Dineshram R, Wong K, Xiao S, Yu Z, Qian PY,&Thiyagarajan V. 2012, Analysis of Pacific oyster larval proteome and its response to high-CO2.
64(10): 2160-7.
6.&Wu, X., X. Li, L. Li, Z. Yu*, 2012, A unique tRNA gene family and a novel, highly expressed ORF in the mitochondrial genome of the silver-lip pearl oyster, Pinctada maxima (Bivalvia: Pteriidae). Gene 510: 22-31.
7.&Yu, F., Y. Zhang and Z. Yu*, 2012, Characteristics and expression patterns of the Lipopolysaccharide-induced TNF-αfactor (LITAF) gene family in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 33:899-908.
8.&Wu, X., X. Li, L. Li, X. Xu, J. Xia, Z. Yu*, 2012, New features of Asian Crassostrea oyster mitochondrial genomes: a novel alloacceptor tRNA gene recruitment and two novel ORFs. Gene 507: 112-118.
9.&Li, X., X. Wu and Z. Yu*, 2012, Complete mitochondrial genome of the Asian green mussel Perna viridis (Bivalvia, Mytilidae). Mitochondrial DNA. 23(5): 358-60.
10. Xu, X., X. Wu and Z. Yu, 2012, Comparative studies of the complete mitochondrial genomes of four Paphia clams and reconsideration of subgenus Neotapes (Bivalvia: Veneridae). Gene 494:17-23.
11.&Fu, D., Y. Zhang, S. Xiao and Z. Yu*, 2011,The first homolog of a TRAF7 (TNF receptor-associated factor 7) gene in a mollusk, Crassostrea hongkongensis. Fish Shellfish Immunol. 31: .
12.&Li, L., Xiao S. and Z. Yu*, 2011, Development of twenty-six microsatellite loci from Crassostrea hongkongensis and cross-species amplification in two closely related species. J Genetics 90 (2): e58-61.
13.&Yu Z.*, X. He, F. Yu and Y. Zhang, 2011, Two superoxide dismutase (SOD) with different subcellular localizations involved in innate immunity in Crassostrea hongkongensis. Fish Shellfish Immunol. 31: 533-539.
14.&Chen J, Xiao S, Z. Yu*, 2011, Cloning of a novel glutathione S-transferase 3 (GST3) gene and expression analysis in pearl oyster, Pinctada martensii . Fish Shellfish Immunol. 31: 823-830.
15.&Chen, J., Xiao S., Z. Yu*, 2011, Molecular cloning, characterization and expression analysis of receptor for activated C kinase 1 (RACK1) from pearl oyster (Pinctada martensii) challenged with bacteria and exposed to cadmium. Fish Shellfish Immunol. 31: 781-787.
16.&&Zhang, Y., D. Fu, F. Yu, Q. Liu, Z. Yu*, 2011, Two catalase homologs are involved in host protection against bacterial infection and oxidative stress in Crassostrea hongkongensis. Fish Shellfish Immunol. 31:894-903.
17.&&He, X., Y. Zhang, F. Yu, Z. Yu*, 2011, A novel sialic acid binding lectin from Hong Kong oyster (Crassostrea hongkongensis) with anti-bacterial activity. Fish Shellfish Immunol. 31:.
18.&Fu, D., J. Chen, Y. Zhang, Z. Yu*, 2011, Cloning and expression of a heat shock protein (HSP) 90 gene in the haemocytes of Crassostrea hongkongensis under osmotic stress and bacterial challenge. Fish Shellfish Immunol. 31: 118-125.
19.&Zhang, Y., X. He, Z. Yu*, 2011, Two homologues of inhibitor of NF-kappa B (IκB) are involved in the immune defense of the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol 30: .
20.&He, X., Y. Zhang, Z. Yu*, 2011, An Mpeg (Macrophage expressed gene) from the Pacific oyster Crassostrea gigas: molecular characterization and gene expression. Fish Shellfish Immunol. 30:870-876.
21.&Zhang, Y., X. He, X. Li, D. Fu, Chen, J., Z. Yu*, 2011, The second bactericidal permeability increasing protein (BPI) and its revelation of the gene duplication in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 30:954-963.
22.&Chen, J., Xiao S., Z. Yu*, 2011, F-type lectin involved in defense against bacterial infection in the pearl oyster (Pinctada martensii). Fish Shellfish Immunol. 30: 750-754.
23.&Fu, D., Y. Zhang, Z. Yu*, 2011, Cloning and expression analysis of an ubiquitin gene (UbL40) in the haemocytes of Crassostrea hongkongensis under bacterial challenge. Chinese J. Oceano. Limno. 29 (1):80-86.
24.&He, X., Y. Zhang, X. Wu; S. X and Z. Yu*, 2011, Cloning and characterization of two ferritin subunit genes from bay scallop, Argopecten irradians (Lamarck 1819). Mol. Biol. Rep. 38: .
25.&Xiao, S., H. Ma, Z. Yu, 2011, Development of 20 novel microsatellite markers in the Hong Kong oyster, Crassostrea hongkongensis. Conserv. Genet. Res. 3:413-415.
26.&Xu, X., X. Wu, Z. Yu*, 2010, The mitogenome of Paphia euglypta (Bivalvia: Veneridae) and comparative mitogenomic analyses of three venerids. Genome 53 (12): .
27.&Li, L. and Z. Yu*, 2010, Isolation and characterization of twenty-four microsatellite loci in oyster Crassostrea hongkongensis. Conserv. Genet. Res. 2:93-96.
28.&Wu, X., X. Xu, Z. Yu*, X. Kong, Z. Wei, J. Xia, 2010, Comparison of seven Crassostrea mitogenomes and phylogenetic analyses. Mol. Phylogenet. Evol. 57: 448-454.
29.&Yu, Z*., Y. Wang and D. Fu, 2010, Development of Fifty-one novel EST-SSR loci in the Pacific oyster, Crassostrea gigas by data mining from the public EST database. Conserv. Genet. Res. 2:13-18.
30.&He, X., Y. Zhang and Z. Yu*, 2010, In silico cloning, expression of Rieske-like apoprotein gene and protein subcellular localization in the Pacific oyster, Crassostrea gigas. Mol. Biol. Rep. 37:.
31.&Kong, X., X. Dong, Y. Zhang, W. Shi, Z. Wang and Z. Yu, 2009, A novel rearrangement in the mitochondrial genome of tongue sole, Cynoglossus semilaevis: control region translocation and a tRNA gene inversion. Genome 52: 975-984.
32.&Ma, H. and Z. Yu*, 2009, Isolation and characterization of twenty-three microsatellite loci in the noble scallop, Chlamys nobilis. Conserv. Genet. Res. 1: 131-134.
33.&Wu, X, X. Xu, Z. Yu*, J. Xia and X. Kong, 2009. Comparative mitogenomic analyses of three scallops (Bivalvia: Pectinidae) reveal high level variation of genomic organization and a diversity of transfer RNA gene sets. BMC Res. Note 2, 69: 7 pp.
34.&Li, Y., X. Kong, Z. Yu et al., 2009, Genetic diversity and historical demography of Chinese shrimp Feneropenaeus chinensis in Yellow Sea and Bohai Sea based on mitochondrial DNA analysis. Afr. J. Biotechnol. 8 (7): .
35.&Wang, Y., Z. Yu* and Z. Liu, 2009, Isolation and characterization of twelve microsatellite loci in the noble scallop, Chlamys nobilis. Aquac. Res. 40: 744-747.
36.&Ma, H. and Z. Yu*, 2009, Development of twenty-two polymorphic microsatellite loci in the noble scallop, Chlamys nobilis. Conserv. Genet. 10: .
37.&Xia, J. X. He and Z. Yu*, 2009, Isolation and characterization of fourteen novel microsatellite loci in the Hong Kong oyster, Crassostrea hongkongensis Conserv. Genet. 10: .
38.&Xia, J. and Z. Yu*, 2009, Identification of seven Crassostrea oysters from the South China Sea using PCR- RFLP analysis. J. Mollus. Stud. 75: 139-146.
39.&Yu, Z., Z. Wei, X. Kong, W. Shi, 2008, Complete mitochondrial DNA sequence of oyster Crassostrea hongkongensis - a case of “Tandem duplication -random loss” for genome rearrangement in Crassostrea? BMC Genomics 9, 477: 13 pp.
40.&Wang, Y., R. Ren and Z. Yu*, 2008, Bioinformatic mining of EST-SSR loci in the Pacific oyster, Crassostrea gigas. Anim. Genet. 39: 287-289.
41.&Yu, Z.*, X. Kong, X. Wei, 2007, Application of the first internal transcribed spacer (ITS-1) of ribosomal DNA as a molecular marker to population analysis in Zhikong scallop, Chlamys farreri. Acta Oceanol. Sinica. 26: 93-100.
42.&Kong, X., J. Yu, Z. Yu* et al., 2007, Comparative analysis of 5’-end sequence of mitochondrial control region of six flatfish species (Pleuronectidae) from the Yellow Sea and phylogentic analysis of Pleuronectiformes. Raffles Bull. Zool. Suppl. 14: 111-120.
43.&Yu, Z. and X. Guo, 2006, Identification and mapping of disease-resistance QTLs in the Eastern oyster, Crassostrea virginica Gmelin. Aquaculture 54:160-170.
44.&Yu, Z., Kong, X., Y. Jiang et al., 2005, Mitochondrial DNA sequence variation of Japanese anchovy (Engraulis japonicus) from the Yellow Sea and East China Sea. Fish. Sci. 71: 299-307.
45.&Zhang, L., X. Kong, Z. Yu* et al., 2004, A survey of genetic changes and search for sex-specific markers by AFLP and SAMPL in a breeding program of Chinese shrimp (Penaeus chinensis). J. Shellfish Res. 23: 897-902.
46.&Lapègue, S., F. M. Batista, S. Heurtebise, Z. Yu and P. Boudry, 2004, Evidence for the presence of the Portuguese oyster, C. angulata, in Northern China. J. Shellfish Res. 23: 759-764.
47.&Yu, Z. and X. Guo, 2004, Genetic analysis of selected strains of the Eastern oyster (Crassostrea virginica Gmelin) using AFLP and microsatellite markers. Mar. Biotechnol. 6:575-586.
48.&Yu, Z. and X. Guo, 2003, Genetic linkage map of the Eastern oyster, Crassostrea virginica Gmelin. Biol. Bull. 204: 327-338.
49.&Yu, Z.*, X. Kong, L. Zhang, X. Guo and J. Xiang, 2003, Taxonomic status of four Crassostrea oysters from China as inferred from mitochondrial DNA sequences. J. Shellfish Res. 22: 31-38.
50.&Kong, X., Z. Yu*, Y. Liu and L. Chen, 2003, Intraspecific genetic variation in mitochondrial 16S ribosomal gene of Zhikong scallop Chlamys farreri. J. Shellfish Res. 22: 655-660.
&承担科研项目情况：
1. NSFC-广东联合基金项目 近江牡蛎广盐高温耐受/适应性及高效生物矿化的基因资源发掘国家与分子调控研究 2013-16
2. 873计划子课题 基于全基因组信息的贝类遗传选育 2012-15
3. 973计划课题 贝类抗病和抗逆的关键基因及其网络调控机制 2010-14&4. 院知识创新工程重要方向项目子课题 牡蛎养殖生产与初级生产力的关系 2009-11&5. 国家公益性行业专项 贝类良种选育体系建设 2008-10&6. 国家现代农业技术体系建设专项 国家贝类产业技术研发中心 2008-15&7. 国家海洋生物技术863项目香港巨牡蛎优质、高产、抗逆品种的培育 2006-10&8. 中国科学院资助项目 中国科学院“百人计划”入选者研究课题， 2005-08&9. 国家自然科学基金项目 太平洋牡蛎多态EST标记开发及其基因组作图研究 2006-08&10. 国家自然科学基金项目 华贵栉孔扇贝微卫星分子标记开发及连锁图构建 2008-10&11. 广东省自然科学基金重点课题 近江牡蛎基因组和EST微卫星标记开发及连锁图构建 2009-11&12. 广东省科技计划项目 近江牡蛎高生长率品种的良种选育及应用示范 2008-10&
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The complete enzyme (apoprotein + cofactor) is termed the holoenzyme
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The complete enzyme (apoprotein + cofactor) is termed the holoenzyme
The complete enzyme (apoprotein + cofactor) is termed the holoenzyme
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