NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key... - Abstract - Europe PMC
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(PMID: PMCID:PMC54***9)
Margaret J Ochocinska
National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Dr., Room 9149, Bethesda, MD, , USA. Margaret.Ochocinska@nih.gov.
Berislav V Zlokovic
Zilkha Neurogenetic Institute, Los Angeles, CA, USA.
Peter C Searson
Johns Hopkins School of Medicine, Baltimore, MD, USA.
A Tamara Crowder
Richard P Kraig
University of Chicago Medical Center, Chicago, IL, USA.
Julia Y Ljubimova
Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Todd G Mainprize
Sunnybrook Health Science Centre, Toronto, ON, Canada.
William A Banks
University of Washington, Seattle, WA, USA.
Ronald Q Warren
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Andrei Kindzelski
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
William Timmer
National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Christina Liu
National Cancer Institute
National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Dr., Room 9149, Bethesda, MD, , USA. Margaret.Ochocinska@nih.gov.
Zilkha Neurogenetic Institute, Los Angeles, CA, USA.
Johns Hopkins School of Medicine, Baltimore, MD, USA.
Combat Casualty Care Research Program, Fort Detrick, MD, USA.
University of Chicago Medical Center, Chicago, IL, USA.
Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Sunnybrook Health Science Centre, Toronto, ON, Canada.
University of Washington, Seattle, WA, USA.
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
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[01 May ):12]
review-article, Review, Journal Article
A trans-agency workshop on the blood-brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute and the Combat Casualty Care Research Program at the Department of Defense, was conducted in Bethesda MD on June 7-8, 2016. The workshop was structured into four sessions: (1) (2)
(3) next generation in vitro blood-brain barrier (BBB) and (4) BBB delivery and targeting. The first day of the workshop focused on the physiology of the blood and neuro-vascular unit, blood or biofluid-based molecular markers, extracellular vesicles associated with brain injury, and how these entities can be employed to better evaluate injury states and/or deliver therapeutics. The second day of the workshop focused on technical advances in in vitro models, BBB manipulations and nanoparticle-based drug carrier designs, with the goal of improving drug delivery to the central nervous system. The presentations and discussions underscored the role of the BBI in brain injury, as well as the role of the BBB as both a limiting factor and a potential conduit for drug delivery to the brain. At the conclusion of the meeting, the participants discussed challenges and opportunities confronting BBI translational researchers. In particular, the participants recommended using BBI translational research to stimulate advances in diagnostics, as well as targeted delivery approaches for detection and therapy of both brain injury and disease.
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