Recurrent ovarian cyst and mutation of the Gs[alpha] gene in ovarian cyst fluid cells: what is the link with McCune-Albright syndrome? - Pienkowski - 1997 - Acta Paediatrica - Wiley Online Library
Advertisement
Advertisement
Isolated peripheral precocious puberty due to recurrent ovarian cysts evokes a McCune-Albright syndrome (MAS). This syndrome associates endocrine dysfunction such as precocious puberty, polyostotic fibrous dysplasia, and &&caf&-au-lait& skin lesions. We report the case of a 3-y-old girl who presented with peripheral puberty with extremely elevated oestradiol level, low LH and FSH levels, and an ovarian cyst that quickly resolved. Skeletal X-rays were normal and she had no caf&-au-lait spots. GnRH analogue treatment was ineffective. A second ovarian cyst appeared and was completely drained under ultrasonographic guidance. Molecular biological analysis performed on fluid cells revealed the Arg201&His mutation of the Gsa gene described in MAS. Percutaneous aspiration of simple ovarian cyst to detect&&MAS& mutation is of interest in the diagnosis of recurrent ovarian cyst.您的位置： &
温家宝提出：确保出口退税改革顺利进行五条措施
优质期刊推荐