Suggestion and healing. - Abstract - Europe PMC
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(PMID:6514534)
[01 Jan ):121-126]
Journal Article
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Show all itemsCrosstalk between adipose tissue and blood vessels in cardiometabolic syndrome: implication of... - Abstract - Europe PMC
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Sarah Elisabeth Louise Even
Maria Gabriela Dulak-Lis
Rhian Touyz
Aurelie Nguyen Dinh Cat
[01 Aug ):89-101]
Research Support, Non-U.S. Gov't, Review, Journal Article
Crosstalk between adipose tissue and blood vessels is vital to vascular homeostasis and is disturbed in cardiovascular and metabolic diseases such as hypertension, diabetes and obesity. Cardiometabolic syndrome (CMS) refers to the clustering of obesity-related metabolic disorders such as insulin resistance, glucose and lipid profile alterations, hypertension and cardiovascular diseases. Mechanisms underlying these associations remain unclear. Adipose tissue associated with the vasculature [known as perivascular adipose tissue (PVAT)] has been shown to produce myriads of adipose tissue-derived substances called adipokines, including hormones, cytokines and reactive oxygen species (ROS), which actively participate in the regulation of vascular function and local inflammation by endocrine and/or paracrine mechanisms. As a result, the signaling from PVAT to the vasculature is emerging as a potential therapeutic target for obesity and diabetes-related vascular dysfunction. Accumulating evidence supports a shift in our understanding of the crucial role of elevated plasma levels of aldosterone in obesity, promoting insulin resistance and hypertension. In obesity, aldosterone/mineralocorticoid receptor (MR) signaling induces an abnormal secretion of adipokines, ROS production and systemic inflammation, which in turn contribute to impaired insulin signaling, reduced endothelial-mediated vasorelaxation, and associated cardiovascular abnormalities. Thus, aldosterone excess exerts detrimental metabolic and vascular effects that participate to the development of the CMS and its associated cardiovascular abnormalities. In this review, we focus on the physiopathological roles of corticosteroid receptors in the interplay between PVAT and the vasculature, which underlies their potential as key regulators of vascular function.
Canadian Institutes of Health Research
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Show all itemsProject MUSE - Yankee Rebel: The Civil War Journal of Edmund DeWitt Patterson (review)
Yankee Rebel: The Civil War Journal of Edmund DeWitt Patterson (review)
pp. 277-279 |
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BOOK REVIEWS277 fine paper, good binding and interesting ülustrations. (There are even references to the 29th U.S. Colored Infantry which had several companies from IlUnois.) Certainly it is an important contribution to the epic of the Civü War. Wayne C. Temple Springfield, Illinois Yankee Rebel: The Civil War Journal of Edmund DeWitt Patterson. Edited by John G. Barrett. (Chapel Hill: University of North Carolina Press, 1966. Pp. xix, 207. $6.00.) Yankee Rebel is the finest personal narrative of Confederate experiences since Henrv Kvd Douglas' / Rode with Stonewall. It glows with its warm accounts of Confederate soldier Ufe, shines in its vivid descriptions of important battles, and sparkles--despite the hardships of camp and prison --with a bright touch of humor. Edmund DeWitt Patterson was an Ohioan who moved to northern Alabama as a teenager. He espoused the cause of the South with the fervor of a convert and enthusiasticaUy joined die Ninth Alabama Infantry in the spring of 1861. He served without special distinction as soldier and Ueutenant (except as wounds are a distinction prized beyond medals by die veteran) through BuU Run, the Peninsular Campaign, the Seven Days, Fredericksburg, ChanceUorsvflle, and Gettysburg. At Gettysburg he was captured and spent from mid-1863 to March, 1865, in Federal prisons at Fort Delaware and at Johnson's Island. With only a rudimentary formal education, Patterson learned to write in a Uterate, forthright style--fuU of natural good humor and emotion and only occasionally burdened by lapses into excesses of Victorian romantic locutions. He wrote pointedly and directly of camp life, excitingly of müitary actions, and with remarkable good spirit and restraint of prison days. This is a diary t Patterson is a Civil War soldier the reader can count as a friend. Most of aU his diary is one easy to quote, and future students of the war will doubtless rum to him for appropriate quotations almost as often as to Douglas, Mrs. Mary Boykin Chesnut, Mrs. Roger Pryor, John Beauchamp Jones, and the other standby Confederate diarists. So much of ill preparation for war does his entry of July 16, 1861 (only three days before First BuU Run), tell: "... I begin to feel tonight the reaUty of war to a certain extent. In the first place, it looks as if someone is to be hurt, by their issuing ammunition to the men. These are the first 'Cartridges' that I have ever seen, and is it possible that we are acruaUy to km men? Human Beings? That these cartridges were made purposelv for one poor mortal to shoot at another? Yes, this is war, and how hardened men must become." So much of the soldier's attitude does he reveal in saying on April 4, 1862: "I am pretty tired and am anxious that folks should quit diis land of 278CIVIL WAR HISTORY foolishness, and go home." And on May 9: 'The rations have joined us, and I am glad enough, for I am tired of stealing corn from the horses when I know that they can't weU do without it" And when he writes of letters from home on November 23: "If any one who has a friend or relative in the company could have seen the faces and heard the remarks of the boys as I distributed die letters I had brought, I am sure that such a one would not faü to embrace the next opportunity of sending a letter. Letters from home or the immediate neighborhood of home have more to do widi keeping up die spirits and morale of the army dian is generaUy supposed . . . . Give the boys letters written in a cheerful honest spirit and they are more conducive to health dian medicine and more potent to prevent desertion that the articles of war which pronounces the sentence of deaui." Quotable passages abound throughout the book. Readers must discover for themselves the sharp images of men in battie, the glimpses of such personages as Jefferson Davis, Alexander H. Stephens, William Lowndes Yancey, Robert E. Lee, James Longstreet, Jeb Stuart, and A. P. HiU. War was not aU fun and games, not aU fraternizing and snow-balling, even to...
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