Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, CAS
Address: 320 Yue Yang Road, Shanghai 200031, P.R. ChinaTel: 86-21-Fax: 86-21-Email: Website:
All Publications
Chen Chu,Lu Yu,Bin Wu,Li Ma,Lantao Gou,Miao He,Yunli Guo,Zhitong Li,Wei Gao,Huijuan Shi,Mofang Liu,Hongyan Wang,Charlie Degui Chen,Jo&l R.Drevet,Yuchuan Zhou,Yonglian Zhang. A sequence of 28 S rRNA-derived small RNAs is enriched in mature sperm andvarious somatic tissues and possibly associates with inflammation. J Mol Cell Biol.(2017)
Yuhang Xing,Runwen Yao,Yang Zhang,Chunjie Guo,Shan Jiang,Guang Xu,Rui Dong,Li Yang,Lingling Chen. SLERT Regulates DDx21 Rings Associated with Pol I Transcription. Cell (4–678.
Yuheng Shi, Bofeng Yuan, Wenting Zhu, Rui Zhang1, Lin Li, Xiaojing Hao, She Chen, Fajian Hou. Ube2D3 and Ube2N are essential for RIG-I-mediated M***S aggregation inantiviral innate immunity. Nat Commun. (2017)
Qing Ye,Quanquan Ji,Wei Yan,Fang Yang,Enduo Wang. Acetylation of lysine ε-amino groups regulates aminoacyl-tRNA synthetase activity in Escherichia coli. J Biol Chem. (2017)
Jingjing Chen, Zhenming Cai, Le Zhang, Yuye Yin, Xufeng Chen, Chao Chen, Yang Zhang, Sulan Zhai,Xuehui Long, Xiaolong Liu，Xiaoming Wang. Lis1 Regulates Germinal Center B Cell Antigen Acquisition and Affinity Maturation. J Immunol. (2017)
Yi Liu,Kai He,Ying Hu,Xiaojie Guo,Dongmei Wang,Weiwei Shi,Jingsong Li,Jianguo Song.
YAP modulates TGF-β1-induced simultaneous apoptosis and EMT through upregulation of the EGF receptor. Sci Rep.(23.
Jiashu Tang, Qingrun Li, Jiaming Li, Jiarui Wu,Rong Zeng. Systematic Synergy of Glucose and GLP-1 to Stimulate Insulin Secretion Revealed by Quantitative Phosphoproteomics. Sci Rep.(8.
Ye Wang,Jufeng Xia,Zhaoyuan Fang,Fei Li,Duo Li,Zuoyun Wang,Yan Feng,Jian Zhang,Haiquan Chen，Hongbin Ji,Hongyan Liu.
A novel BMX variant promotes tumor cell growth and migration in lung adenocarcinoma. Oncotarget. (2017)
Lingbo Wang, Minyin Li, Chao Qu, Wanying Miao, Qi Yin, Jiaoyang Liao, Huateng Cao,Min Huang, Kai Wang, Erwei Zuo, Guangdun Peng, Shuxin Zhang, Guodong Chen, Qing Li, Ke Tang,Qian Yu, Zhoujie Li, Catherine CL Wong, Guoliang Xu, Naihe Jing, Xiang Yu, Jinsong Li.
CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development. Cell Res. (2017)
Qiaoshi Lian, Jun Xu, Shanshan Yan, Min Huang, Honghua Ding, Xiaoyu Sun, Aiwei Bi, Jian Ding, Bing Sun, Meiyu Geng. Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation. Cell Res. (2017)
Xingdong Guo, Chengsong Yan, Hua Li, Wenmao Huang, Xiaoshan Shi, Min Huang, Yingfang Wang, Weiling Pan, Mingjun Cai, Lunyi Li, Wei Wu, Yibing Bai, Chi Zhang, Zhijun Liu, Xinyan Wang, Xiaohui F Zhang, Chun Tang, Hongda Wang, Wanli Liu, Bo Ouyang, Catherine C Wong, Yi Cao，Chenqi Xu. Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor. Cell Res. (–525.
Rongkuan Hu, Huan Yan, Xiaoyan Fei, Haiyang Liu,Jiarui Wu. Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase. Sci Rep. (2017)
Jiajun Xu, Xue Hao, Mengxin Yin, Yi Lu, Yunyun Jin, Jinjin Xu, Ling Ge, Wenqing Wu, Margaret Ho, Yingzi Yang, Yun Zhao, Lei Zhang. Function of Nerfin-1 in preventing medulla neurons dedifferentiation requires its inhibition of Notch activity. Development. (2017)
Cong Chen, Peili Gu, Jian Wu, Xianyun Chen, Shuangshuang Niu, Hong Sun, Lijie Wu, Na Li, Junhui Peng, Shaohua Shi, Cuiying Fan, Min Huang, Catherine C.L.Wong, Qingguo Gong, Chandan Kumar-Sinha, Rongguang Zhang, Lajos Pusztai, Rekha Rai, Sandy Chang, Ming Lei. Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer. Nat Commun. (2017)
Ye Tao,Chen Zhong,Junjun Zhu,Shutong Xu,Jianping Ding. Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2. Nucleic Acids Res. (2017)
Shi Qianqian, Zhang Chuanchao, Peng Minrui, Yu Xiangtian, Zeng Tao, Liu Juan, Chen Luonan. Pattern fusion analysis by adaptive alignment of multiple heterogeneous omics data. Bioinformatics. (2017)
Shenda Hou, Shiyu Zhou, Zhen Qin, Liu Yang, Xiangkun Han, Shun Yao, Hongbin Ji. Evidence, Mechanism, and Clinical Relevance of the Transdifferentiation from Lung Adenocarcinoma to Squamous Cell Carcinoma. Am J Pathol.(2017)
Zhubing Shi, Feng He, Min Chen, Long Hua, Wenjia Wang, Shi Jiao, Zhaocai Zhou. DNA-binding mechanism of the Hippo pathway transcription factor TEAD4. Oncogene. (2017)
Qing Cai, Yuanyuan Li, Gang Pei. Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response.
J Neuroinflammation.(2017)
Siwei Luo,Zhi Liang,Jiarui Wu. Simultaneously measuring multiple protein interactions and their correlations in a cell by Protein-interactome Footprinting.Sci Rep. (69
Lingfei Zhang,Shuai Jiang,Mofang Liu. MicroRNA regulation and analytical methods in cancer cell metabolism. Cell Mol Life Sci. (2017)
Shuyi Ji, Linying Zhu, Yimeng Gao, Xiaoran Zhang, Yupeng Yan, Jin Cen, Rongxia Li, Rong Zeng, Lujian Liao, Chunhui Hou, Yawei Gao, Shaorong Gao, Gang Wei, Lijian Hui. Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening.
Xiangyuan Liu, Min Chen, Long Li, Liyan Gong, Hu Zhou and Daming Gao.
ERK Kinases Phosphorylate Lin28a to Modulate P19 Cell Proliferation and Differentiation.
J Biol Chem. (2017)
Longfei Gao,Wuqiang Guan,Min Wang,Huihan Wang,Jiali Yu,Qing Liu,Binlong Qiu,Yongchun Yu,Yifang Ping,Xiuwu Bian,Li Shen,and Gang Pei. Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules.
Stem Cell Reports.(2017)
Rekha Rai, Chunyi Hu, Cayla Broton, Yong Chen, Ming Lei, Sandy Chang. NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres. . (-17.
Zhan Xu, Matthew B. Greenblatt, Guang Yan, Heng Feng, Jun Sun, Sutada Lotinun, Nicholas Brady, Roland Baron, Laurie H. Glimcher, Weiguo Zou. SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. . (70.
Jun Chen, Shengbao Suo, Patrick PL Tam, Jingdong J Han, Guangdun Peng, Naihe Jing. Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq. . (–580.
Lingling Chen, Li Yang. ALUternative regulation for gene expression. . (2017)
Chen Fan, Xiaohua Ye, Zhiqiang Ku, Liangliang Kong, Qingwei Liu, Cong Xu, Yao Cong, Zhong Huang. Beta-propiolactone inactivation of coxsackievirus A16 induces structural alteration and surface modification of viral capsids. . (2017)
Lin Zhang, Qin Huang, Jiatao Lou, Liangjian Zou, Yiguo Wang, Peng Zhang, Guang Yang, Junyi Zhang, Lan Yu, Dai Yan, Chenyi Zhang, Jing Qiao, Shuting Wang, Sai Wang, Yongdong Xu, Hongbin Ji, Zhengjun Chen, Zhe Zhang. A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis. . (2017)
Xiongjun Wang, Yunbo Qiao, Minzhe Xiao, Lingbo Wang, Jun Chen, Wenjian Lv, Li Xu, Yan Li, Yumei Wang, Mingdian Tan, Chao Huang, Jinsong Li, Ting C. Zhao, Zhaoyuan Hou, Naihe Jing, Y. Eugene Chin. Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells. . (-946.
Tengfei Ma, Yingjie Peng, Wei Huang, Yabing Liu, Jianping Ding. The β and γ subunits play distinct functional roles in the α2βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase. . (82.
Zhanyu Ding, Zhenglin Fu, Cong Xu, Yifan Wang, Yanxing Wang, Junrui Li, Liangliang Kong, Jinhuan Chen, Na Li, Rongguang Zhang, Yao Cong. High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx. . (2017)
Tengfei Ma, Yingjie Peng, Wei Huang, Jianping Ding. Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase. . (21.
Feng Wang, Xing Fu, Peng Chen, Ping Wu, Xiaojuan Fan, Na Li, Hong Zhu, Ting-Ting Jia, Hongbin Ji, Zefeng Wang, Catherine C L Wong, Ronggui Hu, Jingyi Hui. SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling. . (2017)
Bo Yang, Sixiu Chen, Ming Wu, Lin Zhang, Mengna Ruan, Xujiao Chen, Zhengjun Chen, Changlin Mei, Zhiguo Mao. PHF14: an innate inhibitor against the progression of renal fibrosis following folic acid-induced kidney injury. . (88.
Shichao Huang, Jianxin Mao, Kan Ding, Yue Zhou, Xianglu Zeng, Wenjuan Yang, Peipei Wang, Cun Zhao, Jian Yao, Peng Xia, Gang Pei. Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease. . (-94.
Shi Jiao, Chuanchuan Li, Qian Hao, Haofei Miao, Lei Zhang, Lin Li, Zhaocai Zhou. VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. . (58.
Xiaoyan Xu, Lei Han, Guixian Zhao, Shengjie Xue, Yunzhen Gao, Jun Xiao, Shicheng Zhang, Peng Chen, Zhiying Wu, Jianping Ding, Ronggui Hu, Bin Wei, Hongyan Wang. LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis. . (9-226.
Jingyao Zhao, Xufeng Chen, Guangrong Song, Jiali Zhang, Haifeng Liu, Xiaolong Liu. Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes. . (,E142-E151.
Qinggang Dai, Furong Xie, Yujiao Han, Xuhui Ma, Siru Zhou, Lingyong Jiang, Weiguo Zou, Jun Wang. Inactivation of Raptor/mTORC1 signaling in osteoclasts increases bone mass by inhibiting osteoclast differentiation in mice. . (6-204.
Peng Yuan, Xiaohong He, Yefei Rong, Jing Cao, Yong Li, Yunping Hu, Yingbin Liu, Dangsheng Li, Wenhui Lou, Mofang Liu. KRAS-NF&B-YY1-miR-489 signaling axis controls pancreatic cancer metastasis. . (-111.
Hongli Hu, Wenwei Zhu, Jun Qin, Min Chen, Liyan Gong, Long Li, Xiangyuan Liu, Yongzhen Tao, Huiyong Yin, Hu Zhou, Lisha Zhou, Dan Ye, Qinghai Ye, Daming Gao. Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis. . (-528.
Ji Liang, Ruixiu Cao, Xiongjun Wang, Yajuan Zhang, Pan Wang, Hong Gao, Chen Li, Fan Yang, Rong Zeng, Ping Wei, Dawei Li, Wenfeng Li, Weiwei Yang. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. . (-351.
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